Analgesic activity of newly synthesized piperidinium derivatives in mice

ABSTRACT

Two chemically synthesized piperidinium derivatives i.e. 1-methyl-1 [4-nitro] phenacy1 4-hydroxy piperidinium bromide and 1-methyl-1 [4-bromo] phenacyl 4-hydroxy piperidinium bromide were tested for their analgesic activity in intact albino mice by tail flick latency in tail immersion method. All the compounds were administered orally in the doses of 50 mg/kg. Pethidine 50 mg/kg was used as a reference drug for comparison purpose. The results showed that both of these compounds exhibit a highly significant activity