Effect of passive immunization with specific anti-FSH on tes-ticular lipids and some lipogenic enzymes of adult bonnet monkeys
IBJ-Iranian Biomedical Journal. 1998; 2 (1): 39-44
in English
| IMEMR
| ID: emr-48111
ABSTRACT
The effect of anti-follicular stimulating hormone [FSH] on testicular lipid and the specific activity of testicular enzymes of the isocitrate dehydrogenase [ICDH], pyruvate/malate dehydrogenase [MDH] and malic enzyme involved in lipogenesis were studied in mature bonnet monkeys, Macaca radiata. Immunization of monkey with anti-FSH for 24 days did not produce any significant changes in the body weight, organ weight and pituitary weight. Testicular isocitrate dehydrogenase [ICDH] and malic enzyme activities were decreased significantly but MDH activity was stimulated by anti-FSH treatment. Testicular total lipid, phospholipid and cholesterol, were not altered significantly by the Anti-FSH treatment. Increased level of free cholesterol were also observed after FSH treatment. Among glyceride glycerol sub classes, triacyl glycerol showed a significant increase. Among testicular phospholipid classes, phosphatidyl inositol was markedly decreased by anti-FSH immunization. Data on serum hormonal profile, shows that there were no alteration in serum testosterone, prolactin [PRL] and luteinizing hormones [LH] but FSH was significantly decreased. The present study reveals that immunization with anti-FSH has significant effect on different class of testicular lipids and pyruvate malate enzymes cycle
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Testis
/
Immunization, Passive
/
Follicle Stimulating Hormone
/
Lipids
/
Macaca radiata
Limits:
Animals
Language:
English
Journal:
Iran. Biomed. J.
Year:
1998
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