comparative study of n-acetylcysteine and two new antidotes [zinc and hepanox] on acetaminophen hepatotoxicity in rats

ABSTRACT

Sixty mature albino rats were divided equally into five test groups and one control group. Acetaminophen was given orally [100 mg/kg] to rats of the five test groups. N-acetylcysteine [150mg/kg], zinc sulphate [15mg/kg]; combined zinc sulphate and N-acetylcysteine with the same doses and hepanox [150 mg/kg] ere given orally one hour after the toxic acetaminophen dose to rats of the second; third; fourth and fifth groups respectively. Statistical analysis of values of serum Alt, ast, ldh AND g-6-P-D showed high signifidcant elevation in the first test group [acetaminoiphen], significant decrease in the second DD[N-acetylcysteine] and third [zinc sulphate] groups and dramatic significant improvement in the fourth [combined N-acetylcysteine and zinc sulphate] and fifth [hepanox] groups. All biochemical results coincided completely and confirmed by the histopathological findings in the livers of the studied rats