Subacute subchronic toxicity of formaldehyde by inhalation in male albino rats: histopathological and image analysis studies on nasal mucosa
MJFCT-Mansoura Journal of Forensic Medicine and Clinical Toxicology. 1998; 6 (1): 71-93
in English
| IMEMR
| ID: emr-48949
ABSTRACT
This study aimed to evaluate the inhalation toxicity to the nasal epitheliumof rats, formaldehyde [HCHO] at a high concentration for both short andmoderate periods. 24 adult male albino rats were exposed to a concentrationof 30 ppm formaldehyde vapor during 6 hours/day, 5 days/week for successive 4,8 and 12 weeks, respectively. Histopathological examination as well asassessment of the DNA content of mucosal nuclei using the computerized imageanalysis [IA] system were both done. Histopathological examination revealedthat the aldehyde produced both involutional changes, such as erosion andatrophic epithelium, and proliferative reactions, such ashyperplastic-metaplastic as well as dysplastic lesions. Furthermore, all thelesions elaborated diploid histograms with variable degree of statisticallysignificant increases of mucosal cells at the S- phase compared with thecontrol. Therefore, the results indicated that there was an increasedreactivity of the nasal mucosal cells towards formaldehyde vapor
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Administration, Inhalation
/
Histology
/
Nasal Mucosa
Limits:
Animals
Language:
English
Journal:
Mansoura J. Forensic Med. Clin. Toxicol.
Year:
1998
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