Isoelectrofocusing method for detection of inter-alpha-trypsin inhibitor polymorphism among Egyptians

ABSTRACT

In this study, inter-alpha inhibitor [ITI] phenotypes were demonstrated in 150unrelated Egyptian subjects using isoelectrofocusing on polyacrylamide gelwith subsequent immunofixation and silver staining. Thirteen phenotypes wereobtained in this study controlled by six alleles. The most common phenotypeswere 1/2 and 1/1 with frequency of 0.46 and 0.30, respectively, while the mostcommon alleles encountered in the present population sample were ITI*1 and ITI*2 with the frequency of 0.530 and 0.350, respectively. A rare allele ITI*6 was described with a frequency of 0.013. It was concluded that ITI protein polymorphism is of a great potential value for forensic purposes: