Drugs causing fixed eruption in children. a study of 31 cases

ABSTRACT

This is the largest series of fixed drug eruption [FDE] in children ever reported from one centre. Out of thirty five clinically diagnosed cases of FDE, 31 patients were positive to oral provocation tests. Cotrimoxazole was the commonest cause of FDE. Other incriminated drugs were paracetamol, acetylsalicylic acid, phenylbutazone, ampicillin, amoxycillin, tetracycline, metamizole and mefenamic acid. Cross-sensitivity was seen between penicillin derivatives; Polysensitivity with various drugs was observed in 4 cases [12.8 percent]. Cross-sensitivity between ampicillin/amoxycillin and polysensitivity among different drugs are still unreported