Clinical profile of non-insulin dependent [Typ-II] diabetes mellitus at Mayo Hospital Lahore

ABSTRACT

Non-Insulin Dependant Diabetes Mellitus [NIDDM] is a major metabolic disorder. Insulin resistance is the primary abnormality predisposing to NIDDM. Genetic factors as well as environmental agents cause NIDDM in man. Hyperglycemia leads to development of complications. Present study was aimed to investigate NIDDM from a population perspective as a risk factor for development of complications. The study was conducted on 48 subjects. They were NIDDM patients and non-diabetic relative of type-II diabetics. Clinical symptoms, complications and blood glucose levels were recorded. Fifteen percent [15%] of NIDDM patients did not have a positive family history of diabetes. On diet control alone presented with more complications. There was statistically highly significant difference [p<0.01] in age of onset and total duration of diabetes between patients on oral hypoglycemics and on diet control. Body Mass Index [BMI] was higher in diabetics as compared to non-diabetics [p< 0.01]. Complete physical examination and routine glycosylated haemoglobin [HbA1C] should be carried out on regular basis to avoid development of complications