Stability indicating methods for the quantitative determination of pseudoephedrine HCl and guaifenesin and dextromethorphan HBR in a cough syrup using HPLC
SPJ-Saudi Pharmaceutical Journal. 1998; 6 (1): 53-59
in English
| IMEMR
| ID: emr-49799
ABSTRACT
The determination of three active ingredients in a multicomponent pharmaceutical product by HPLC using two columns is reported. Guaifenesin and dextromethorphan HBr were separated and quantitated simultaneously in a cough syrup using an isocratic reversed phase system. The mobile phase was 45% [v/v] aqueous methanol with ammonium formate as buffer [PH 4.3]. the range of concentrations used in the determination of guaifenesin and dextromethorphan HBr were 202-363 mg/100ml and 30-54 mg/100 ml, respectively. A separate method was developed for the determination of pseudoephedrine HCI using a normal phase system. The mobile phase was 80% [v/v] aqueous ethanol with ammonium acetate as buffer [pH 7.3]. the range of concentrations used in the determination of pseudoephedrine HC1 was 60-108 mg/100 ml. Both methods proved to be repeatable, reproducible and stability indicating
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Cough
/
Dextromethorphan
/
Drug Combinations
/
Drug Stability
/
Ephedrine
/
Guaifenesin
Language:
English
Journal:
Saudi Pharm. J.
Year:
1998
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