Local anesthetic and antiarrhythmic activity of certain new 1,3,4-thiadiazole derivatives

Magda A., El Sherbeny; Abdul Rahman M.A., Al Obaid; Hassan A., El Kashef

Magda A., El Sherbeny; Abdul Rahman M.A., Al Obaid; Hassan A., El Kashef.

SPJ-Saudi Pharmaceutical Journal. 1998; 6 (3-4): 228-34

in English | IMEMR | ID: emr-49821

ABSTRACT

ABSTRACT

A series of 2-[1-oxo-2-[substitutedamino] ethylamino and 2- or 3-[substitutedamino] propylamino] 5 trifluoromethy1-1,3,4-thiadiazoles [5a-f, 6a-f and 7a-f] was synthesized and evaluated for their local anesthetic and antiarrhythmic activity. Some of the tested compounds showed promising activity. The detailed synthesis, spectroscopic and biological data are reported

Subject(s)

Thiadiazoles/pharmacology; Anesthetics, Local/pharmacology; Anti-Arrhythmia Agents/pharmacology

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Index: IMEMR (Eastern Mediterranean) Main subject: Thiadiazoles / Anesthetics, Local / Anti-Arrhythmia Agents Language: English Journal: Saudi Pharm. J. Year: 1998

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Index: IMEMR (Eastern Mediterranean) Main subject: Thiadiazoles / Anesthetics, Local / Anti-Arrhythmia Agents Language: English Journal: Saudi Pharm. J. Year: 1998