Some changes of impotent alloxan induced diabetic male rats

ABSTRACT

In this study three groups of adult male rats were used; the first as control, the second was of impotent rats of alloxan-induced diabetes under control by insulin and the third was like the second, but without insulin. The serum level of glucose, testosterone, prolactin, L.H, F.S.H, penile nitric oxide synthase enzyme and the weights of whole body, testis, adrenals, prostate and penis were estimated. The glucose level was significantly increased in both impotent groups due to effect of diabetes and was more significantly higher in the third group due to no treatment by insulin. The other parameters showed a significant decrease in both impotence groups when compared with control. There was also a more significant decrease in serum testosterone, penile NOS, weights of adrenal glands, testis, prostate and penis in group 111 than in group II. Testosterone change was due to decrease its formation in the endoplasmic reticulum of Leydig cells, more lipid deposits ultrastructural diabetic change and decrease in human chorionic gonadotrophine receptors. The decrease in prolactin, F.S.H. and L.H. was due to affection of their releasing hormones. As for the penile NOS, its change was due to diabetic effect on putative penile endothelial NOS. The body weight change was due to the diabetic metabolic effect, while the change in weights of adrenal glands, testis, prostate and penis was due to testosterone level decrease [androgenic sensitive organs]