Use of oral misoprostol "prostaglandine1 analogue" in the prevention of post-partum haemorrhage

ABSTRACT

To investigate the use of the oral misoprostol" prostaglandin E1 analogue" in the prevention of post partum haemorrhage. One hundred women undergoing vaginal delivery divided into two graups [1] Study group were given 600 ug misoprostol orally at the end of the second stage of labour. [2] Control group Were given a combination of 5 units oxytocin and 0.5 mg ergometrine intra musculary at the end of the second stage of labour. Post partum haemorrhage occurred in 6% of the women, the need for therapeutic oxytocics in 6%, retained placenta in 2% and the median length of third stage was 5 minutes. Vomiting and diarrhoea in the first hour after delivery occurred in 8% and 4% repectively and shivering in 48% all were self limited. So misoprostol may be effective in the prevention of post partum haemorrhage and has few toleratd side effect