Acta Medica Iranica. 1999; 37 (2): 68-72
in English
| IMEMR
| ID: emr-50103
ABSTRACT
In this study the effect of nitric oxide synthesis inhibition on stress-induced gastric damage was evaluated in bile.duct ligated sham operated and unoperated rats. Animals were injected intraperitoneally with N g nitro-L-arginine methylester [L-NAME] 40 mgl/kg, L-arginine, 200 mg/kg or saline, 30 min before water-immersion stress. One hour after water immersion, the animals were killed and tneir stomachs were removed for measurement of gastric mucosal damage The results showed that L-NAME significantly enhances the development of gastric mucosal lesion in sharm operated and unoperated rats, while in bile duct ligated animals L-NAME decreases and L-arginine enhances the potentiation of stress-induced gastric mucosal damage. The results suggest that inhibition of nitric oxide synthase with L-NAME has different effects on stress-induced gastric damage in cholestatic rats compared with normal animals
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Stress, Physiological
/
Cholestasis
/
Gastric Mucosa
Limits:
Animals
Language:
English
Journal:
Acta Med. Iran.
Year:
1999
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