Evaluation of T lymphocyte subsets in children with beta thalassemia major
Acta Medica Iranica. 1999; 37 (2): 73-77
in English
| IMEMR
| ID: emr-50104
ABSTRACT
Peripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major [age 2-12 years] and compared with 14 age-and sex-matched healthy controls. Three monoclonal antibodies [anti-CD3, anti CD 4, anti -CDS] were simultaneously applied for detection of th [CD3+ CD 4+] Ts/c [CD3+ CD8+] and Th/Ts ratio by flowcytometry respectively. The results of this study showed a slight increase in the number of T lymphocytes, T CD 4+ T CD8+, and CD 4+/CD8+ ratio; but this increase was not statistically significant [P>0.05]. No primary defect in T cell subsets was detected and it was suggested that continuous regulation of iron balance is an important factor in decreasing immunological disturbance
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
T-Lymphocytes
/
Child
/
T-Lymphocyte Subsets
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Acta Med. Iran.
Year:
1999
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