Effect of vitamin A supplementation on the serum levels of some immunoglobulins in vitamin A deficiency children

ABSTRACT

Effect of vitamin A deficiency and of subsequent vitamin A supplementation on the serum levels of immunoglobulins, IgG, IgA, and IgM were studied in children with severe to moderate vitamin A, deficiency. Decreased levels of IgG [P < 0.001], IgA [P < 0.01] and increased levels of serum IgM [P < 0.01] were found in vitamin A deficient children, compared to normal On supplementation of 100,000-200,000 i.u. of vitamin A. during a period of 2 weeks, serum lgG, IgA and IgM levels in the vitamin A deficient children increased by 49.4 +/- 7.2%, 14.2 + 7.7%, and 8.1 + 2.3% respectively with an increase in the serum vitamin A levels by 47.6 + 10.6 per cent. The result have been discussed on the possible interations of vitamin A, deficiency and immunity