[Insulin dependent diabetes mellitus and antibodies to glutamic acid decarboxylase]
Arab Journal of Pharmaceutical Sciences. 1999; 1 (4): 85-94
in English
| IMEMR
| ID: emr-50355
ABSTRACT
Insulin dependent diabetes mellitus [IDDM] is an autoimmune disease, the factors that induce the selective destruction of the insulin producing islet cells of the pancreas are unknown. Although autoreactive T-cells rather than autoantibodies are responsible for the destruction of beta-cells, the identification and chararcterization of the autoantibody-autoantigen system in IDOM are of crucial and fundamental importance in prediction and potential immunotherapy of the disease. Currently, Cytoplasmic Islets Cell Antibodies [ICAs Insulin Autoantibodies [IAA], Glutamic Acid Decarboxylase Antibodies [Anti-GADs] and 37-k antigen antibodies are potentially useful hurnoral markers for such prediction. The attempt to identify the earliest events in the autoimmune process suggest that Anti-GAD could be the first and most important autoantigen
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Autoantibodies
/
Carboxy-Lyases
/
Glutamic Acid
/
Diabetes Mellitus, Type 1
/
Antibodies
Limits:
Humans
Language:
English
Journal:
Arab J. Pharm. Sci.
Year:
1999
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