[Using of C-peptide assay in differential diagnosis of diabetic]

ABSTRACT

To compare fasting C-Peptide [CP] levels as an indicator of beta-cell of the pancreas secretion among different groups of diabetic patients, and to define a cut-off value which may be useful to the proper classification and treatment. 225 type II, 62 secondary failure [SF], and 52 type I patients. Age, BMI, and duration of diabetes were recorded for all patients who had their fasting glucose, creatinine, and CP checked; while fasting insulin was measured only in type II patients. A significant decrease of fasting CP was recorded in SF and typeI compared to type I patients. The value 1.2 ng/lml [0.4 nmo] was highly sensitive in differentiating patients, and may be used when determining treatment protocols. In addition there was an important increase in fasting glucose in SF compared to type II patients that may reflex the importance of endogenous secretion to control HGP [hepatic glucose productin] and the necessity of combined therapy to treat SF patients