Synthsis, antimicrobial and antifungal activities of some pyrimidine derivatives

ABSTRACT

Several chalcones derivatives [1] were prepared from 2, 4-dimethoxyacetophenone, when beta-[4-substituted phenyl]-2, 4-dimethoxyacrylophenone [1] reacted with guanidine hydrochloride, thiourea and urea afforded aminopyrimidine [2], pyrimidinethione [7] and oxopyrimidine [8], respectively. Furthermore, compounds [2], [7] and [8] were subjected to different reactions yielding different pyrimidine derivatives. Representative members of these compounds were subjected to preliminary antimicrobial and antifungal screening and most of these compounds showed significant activities