Antimicrobial flavonoids from solanum dobium fres

ABSTRACT

Two flavonoids compounds were isolated from Solanum dobium Fers [Solanaceae]. One major compound was identified as astragalin [kampferol-3-O-glucoside], and a minor compound that was tentatively identified as quercetin-3-glycoside. The antimicrobial activities of the 2 compounds were tested against 12 microorganisms [7 bacteria, 2 fungi and 3 C and ida of different strains]. The major compound was found to possess a pronounced antibacterial activity as presented by the minimum inhibitory concentration showing activity 4 times as that of streptomycin and double that of tobramycin against Pseudomonas aeruginosa UM 60690. It displayed double activity of streptomycin against both Salmonella typhi UM 26049 and Flavobacterium meningosepticum UM 260494. In addition, the isolated astragalin showed a significant 2-4 times antic and idal activity as compared with nystatin against C and ida intermedia ATCC 5159, C and ida albicans Um 050494, and C and ida lipolytica ATCC 8661. However, this compound did not show any significant antifungal activity. The isolated minor flavonoid showed significant antic and idal, antifungal as well as moderate antibacterial activity