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Stability monitoring of acetaminophen paediatric preparations marketed in Pakistan by using HPLC method
Hamdard Medicus. 1999; 42 (2): 84-89
in English | IMEMR | ID: emr-50790
ABSTRACT
Post-marketing stability studies were conducted on different commercial acetaminophen paediatric preparations collected from the cities of Dera Ismail Khan and Karachi, Pakistan, which differ in their climatic conditions. A properly validated HPLC method developed in our laboratory was used. The mobile phase consisting of 0.05M phosphate buffer methanolhexane-1-sulfonic acid sodium salt in the ratio 850 150 2 [v/v/w], pH adjusted to 3, was pumped at1.5 mI/mm flow. The separation was achieved on a reverse phase C18micro Bondapack 3.9 i.d. x 300 trim column and the aetection wave length was 245 nm. It was concluded that due to warmer climatic conditions the levels of hydrolytic product 4-aminophenol were higher in samples collected from DI. Khan as compared to the samples from Karachi
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Index: IMEMR (Eastern Mediterranean) Main subject: Pediatrics / Product Surveillance, Postmarketing / Chromatography, High Pressure Liquid / Drug Stability Language: English Journal: Hamdard Med. Year: 1999

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Index: IMEMR (Eastern Mediterranean) Main subject: Pediatrics / Product Surveillance, Postmarketing / Chromatography, High Pressure Liquid / Drug Stability Language: English Journal: Hamdard Med. Year: 1999