Changes in the brain cholesterol level induced by different cholesterol derivatives in albino rats

ABSTRACT

Changes in the level of cholesterol in albino rats CNS [cerebrum, cerebellum, brain stem, spinal cord] were evaluated following the administration of three reported derivatives of cholesterol 3beta-acetoxy-cholest 5-ene, 3beta-acetoxy-6-nitro..cholest-5-ene and 3beta-acethxy-5-cholestan-6-one. Experiments were conducted on four groups of six albino rats weighing 250-300 gm. Control rats were administered normal saline ip while the other three experimental groups were given 0.3 mg/kg bw of steroidal solution ip which was prepared in peanut oil