Ciprofloxacin and metronidazol in the treatment of gastroduodenal disorders

ABSTRACT

The study included 42 patients of age range 16-58 years, were selected randomly from the gastroenterology unit. They were suffering of gastrointestinal disorders and diagnosed as having gastritis, duodenal ulcer or duodenitis. Biopsy specimen was taken from the gastrointestinal lesion from each patient to detect Helicobactor pylori infection by the urease test. Significant association was found between Helicobactor pylori infection and the gastrointestinal disorder being diagnosed, as the infection was detected in 85.7% of the total patients. The infection was detected in 94.1%, 76.4% and 87.5% of the patients having gastritis, duodenal ulcer and duodenitis respectively. A new treatment regimen was tried in this study to eradicate Helicobactor pylori infection. Biopsy specimen was taken from each patient after two weeks of treatment to figure out the effect of therapy on the eradication of Helicobactor pylori. The regimen used included a combination ofciprodar [ciprofloxacin 500 mg. b.i.d.] plus flagyl [metronidazol 200mg. q.i.d.] for two weeks. This regimen was found significantly effective in eradicating Helicobactor pylori and resulted in disappearance of signs and symptoms with the healing of the gastrointestinal lesion. This combination therapy resulted in a healing rate of 81.25%. But there was a difference in response between gastritis, duodenal ulcer and duodenitis. Patients with duodenitis were found to be the most responsive to this regimen. The resultant healing rates were 76.9%, 83.7% and 85.7% for gastritis, duodenal ulcer and duodenitis respectively.