Bromocriptine: effect on galactorrheic, hyperprolactenaemic women

ABSTRACT

A prospective observational study was designed to determine the response to Bromocriptine [Parlodel] therapy in terms of occurrence of pregnancy and its outcome in women who had infertility associated with galactorrhea and hyperprolactinaemia. A total of 29 infertile women found to have galactorrhea and hyperprolactinaemia. Out of them 40% had primary infertility and 60% were of secondary infertility. About 27% patients had associated menstrual problems. After excluding or treating other causes of infertility Bromocriptine therapy was instituted with the minimum dose and slowly building up the requried dosage. In 73% [21/29] patients Bromocriptine was prescribed in a dosage of 5 mg per day and 7.5 mg was given to the rest of the cases. Tolerance to Bromocriptine was quite remarkable. Pregnancy was achieved in 48% [11/23] cases, in 36% cases of primary infertility and 64% of secondary infertility. About 82% [9/11] conceptions occurred within 2 to 6 months of therapy and of the 11 pregnancies 9 ended as successful term deliveries. Clomiphene citrate was given to 27% [3/11] patients due to ovulatory dysfunctions