Diclofenac sodium for the treatment of ocular contusion with microhyphema

ABSTRACT

In this study, the effectiveness of topical diclofenac sodium has been investigated in the treatment of microhyphema. A total of 62 patients with traumatic microhyphema were enrolled in a prospective, randomized, double-masked, placebo-controlled clinical study. Of these, 32 were given diclofenac eye drops, while 30 received a placebo. All were observed daily until there was complete recovery. One drop of diclofenac sodium or a placebo was applied four times a day. The efficacy evaluation was based on the measurement of visual acuity, slit-lamp assessment of anterior chamber cells and flare and duration of treatment. Diclofenac sodium was statistically favored over the placebo in flare and cell score. The duration of treatment of the diclofenac group was significantly shorter than the placebo group. Visual acuity of diclofenac sodium recipients was significantly better than the placebo recipients from the third to the sixth day of treatment. No statistical difference in final visual acuity was found between the two groups [P>0.05]. The research indicated that diclofenac sodium reduces microhyphema effectively and more quickly than the placebo, leading to early rehabilitation of patients following ocular contusion