Inhibition of multiplication of leprosy bacilli in nude mice by simultaneous adminstration of new rifamycin derivative krm-1648 and sparfloxacin combined with dapsone

ABSTRACT

The inhibition of multiplication of mycobacterium leprae inculated in to foot pads of nude mice by oral administration of new rifamycin derivative KRM-1648 and a new quinoline, sparfloxacin [SPFX] combined with dapsone [DDS] was examined. When these drugs administered simultaneously once weekly, the use of 0.6 mg/Kg of KRM, 10 mg/kg of sparfloxacin and 0.001/ Dapsone, entirely prevented the multiplication of M. leprae even the number of non solid bacilli detected was less than that inoculated into each foot pad. This study revealed the possible future use of this multi-drug regimen in the chemotherapy of leprosy patient