role of cerB-B-2, BCL-2 and fibronectin immunohistochemical expression in the progression of bladder carcinoma

ABSTRACT

This work aimed to assess the role of cerb-B-2, BC1-2 and fibronectin expression in the progression of bladder carcinomas. It studied 55 bladder carcinoma cases, 22 squamous cell carcinomas and 33 transitional cell carcinomas. Using the Mann-Whitney test, no significant difference was found between squamous cell carcinoma and transitional cell carcinoma regarding the immmnohistochemical scores of cerb-B-2, BCL-2 and fibronectin [pericellular, stromal]. Using the Spearman's correlation test, a direct significant correlation was present between different grades and immunohistochemical expression of cerb-B-2, BCL-2 and stromal fibronectin where rs = 0.873, 0.737 and 0.911. However, an inverse significant correlation was found between different grades and pericellular fibronectin where rs = 0.700. Also, a direct significant correlation was found between the expression of cerb-B-2, BCL-2 and stromal fibronectin and the different stages of bladder carcinoma where rs = 0.893, 0.794 and 0.873]. On the other hand, pericellular fibronectin showed an inverse significant correlation with the different stages where rs = -0.794