Ovulation induction in a woman with premature ovarian failure resulting from a partial deletion of the X chromosome long arm, 46, X, DEL [X] [Q22]

ABSTRACT

In this study, a 27-year old woman was presented with secondary amenorrhea, her secondary sexual characteristics were well developed. The physical examination revealed no Turner somatic stigmata. Endocrine studies showed hypergonadotropic hypogonadism and the serum FSH was 55 mIU/ml, serum LH level was 17 mIU/ml, serum prolactin 4 ng/ml, serum E2 and testosterone [T] levels were undetectable, thyroid and adrenal hormone levels were normal. Cytogenetic studies showed a46,X,del[X] [q22] karyotype in all the 100 lymphocytes analyzed. On the seventh day after discontinuation of hMG treatment, transvaginal US indicated luteinizing appearance of the follicle and thickening of the endometrium [14 mm] and the serum P level was 8.9 ng/mL. On the 14th day after stopping of hMG, menstruation occurred. On the 28th day after the menstruation, the next menstruation took place four days later. In addition, another spontaneous menses occurred on the 30th day after the second menstruation. In conclusion, ovulation induction was possible in patients with premature ovarian failure [POF] caused by X chromosome aberrations