Neuromuscular blocking effects of rocuronium with different inhalation anaesthetics

ABSTRACT

This study was designed to examine the interactions of 1.0 MAC of two different inhalation anesthetic agents, isoflurane and sevoflurane, [and 66% nitrous oxide in oxygen, 20-min steady state] or total intravenous anesthesia [TIVA] using propofol/fentanyl with rocuronium. Neuromuscular function was monitored using relaxograph date, NMT100. Neuromuscular block was monitored by measuring the force of contraction of the abductor pollicis muscle after single-twitch stimulation of the ulnar nerve at 0.1 Hz. The ED50 and ED95 [dose required to produce 50% and 95% depression of twitch tension, respectively] of rocuronium were recorded