Alteration in interleukin-8 and chemotactic factors in renal failure and dialysis patients

ABSTRACT

Serum level of inlerleukin-8 [IL-8] and neutrophil chemotactic function were measured in 60 patients suffering from renal diseases in addition to 15 normal healthy persons served as controls. Patients were subdivided into three groups Group one included patients with renal failure on regular dialysis, group two included patients with chronic renal failure not on dialysis and group three included patients with chronic glomerulonephritis. There was a significant elevation in serum level of IL-8 in all studied patients [43.3 +/- 6.8 pg/ml] in comparison with the control group [11.3 +/- 5 pg/ml] without a statistical difference between the patients groups. Also, there was a significant decrease in neutrophil chemotaxis between all studied patients [42.3 +/- 25.4-m] and controls [70.4 +/- 22.1 -m]. As regards patients' serum affecting the process of chemotaxis, there was a significant decrease between group one and two and there was a significant decrease in neutrophil chemotaxis and in patients' serum affecting the process of chemotaxis between group two and three. Because of this defective chemotaxis, those patients were at increased risk of infection that should be taken into consideration while treating them