Impact of helicobacter pylori on gastric mucosal cell proliferation

ABSTRACT

The interaction of H. Pylori and gastric mucosal proliferation was measured by means of flow cytometry. This study included 40 patients proved to have gastritis by upper GI endoscopy and also had H. Pylori positive in histopathological examination of gastric biopsies. The patients were divided into two groups. The first group [lansoprazole group] included 20 patients who received 30 mg lansoprazole twice daily to remove HCl effect on gastric mucosal cell proliferation. While, the second group [triple therapy group] included 20 patients who received two weeks H. pylori eradication regimen in the form of twice daily 30 mg lansoprazole, clarithromycine [500 mg] and amoxycillin [1 gm]. The flow cytometric analysis showed that H. pylori inhibits gastric mucosal cell proliferation in the proliferation index [PI] and in the S-phase independently on the gastric luminal HCl. The cell cycle analysis has reflected that H. pylori inhibits a crucial event in the cell cycle of gastric mucosa occurring at the GI/S border independently on the HCl production