Relationship of autonomic neuropathy and helicobacter pylori infection in dyspeptic patients with type-2 diabetes mellitus

ABSTRACT

To evaluate the prevalence of Helicobacter pylori [HP] and its relationship with autonomic neuropathy [AN], this work studied 200 patients with type-2 diabetes mellitus [DM type-2] matched for sex, age [ +/- 5 years] and body weight [ +/- 5 Kg] as well as 200 nondiabetic subjects, all affected by dyspepsia of unknown origin. The results documented that the prevalence of peptic ulcer was similar in both groups of patients [20% Vs 25%], chronic gastritis was 36% in diabetic group and 55% in the control group. Non-ulcer and non- gastritis dyspepsia was significantly more frequent in diabetic group than in control group [44% Vs 20%]. Also, in this study, two other tests have been compared with the histological evidence of HP [used as golden standard] i.e. the urease test [CP-test] and the assay of anti- HPG immunoglobulins. Both were positive in a significantly higher percentage in neuropathic diabetic patients in comparison with non- neuropathic diabetic ones