Serum cystatin C as a marker of renal affection in diabetic renal disease

ABSTRACT

This study aimed to assess clinical usefulness of measurement of serum cystatin C as a marker of renal affection in different stages of diabetic renal disease. The study included 40 patients with either types of diabetes mellitus [DM] at different stages of diabetic nephropathy [DN] as well as 20 healthy subjects matched for age and sex as controls. All the participants were investigated for renal function tests [S creatinine, urea, creatinine clearance], urine strip testing for microalbuminuria [Micral test], quantitative 24 hour urinary protein assessment, renal isotope scan by TC99 DTPA to assess GFR and finally an assessment of S cystatin C level by particle enhanced turbidimetric immunoassay [PETIA] technique