prevalence of activated protein C resistance in patients with repeated fetal losses

ABSTRACT

This study was conducted for the prevalence of activated protein C resistance [APCR] on 20 patients with past history of recurrent fetal losses in their first trimester, 13 patients in their second trimester and 20 women with no past history of fetal losses taken as controls. All women were negative for rubella, toxoplasma, cardiolipins IgG and IgM. All patients and controls had normal coagulation profile as regards prothrombin time, APTT, protein C activity, total protein S and antithrombin III. APCR was done for all groups. The prevalence of phenotypic APCR in the first trimester fetal loss group was 5%, while it was 23% in the second trimester fetal loss group. APCR is 5-10 times more common than any of the other known inherited deficiencies of anticoagulant proteins