DNA pattern and estrogen receptor content in perimenopausal dysfunctional uterine bleeding

ABSTRACT

This study was performed on 50 endometrial biopsies divided into two groups Non-hyperplastic group [25 cases] including normal proliferative, secretory, irregular shedding, disordered proliferative and atrophic endometria and hyperplastic group [25 cases] including simple, complex and atypical hyperplastic endometria. The study aimed to correlate between estrogen receptors, DNA activity and histologic pattern in order to give an idea on the most likely type to carry the higher risk of neoplastic transformation. There was no significant association between estrogen receptor [ER] immunoreactivity and proliferative activity except for cases with atypical hyperplasia showing lower ER immunostaining and increasing S-phase fraction. Also, all types of hyperplasia had significantly higher S-phase fraction and proliferative, secretory, irregular shedding, disordered proliferative and atrophic endometria