Matrix-metallo proteinase-9 [MMP-9] [gelatinase B] levels in rheumatoid arthritis useful laboratory marker

ABSTRACT

In an attempt to find a potentially useful serum markers in rheumatoid arthritis which reflect the underlying pathogenic mechanisms, we measured the circulating levels of matrix degrading metalloproteinase-9 [MMP-9] also termed gelatinase B in sera and synovial fluids [SF] from patients with rheumatoid arthritis. The levels of MMP-9 in sera were measured in 20 females patients with active rheumatoid arthritis and in 15 female healthy control subjects, while the levels of MMP-9 in synovial fluid were measured in the same 20 female individuals with active rheumatoid arthritis and compared to 10 patients with noninflammatory joint diseases as a control. There was significant elevation in the levels of MMP-9 in sera of patients compared to controls. There was also significant elevation in the levels of MMP-9 in SF in patients compared to controls. So Matrix Mettalloproteinase-9 can be used as a good marker in cases of rheumatoid arthritis