Assessment of some biochemical parameters of the hepatocellular carcinoma, liver cirrhosis and hepatitis C patients
Scientific Journal of Al-Azhar Medical Faculty [Girls] [The]. 1999; 20 (Supp. 2): 1187-1199
in English
| IMEMR
| ID: emr-52712
ABSTRACT
Hepatitis C virus is a major etiological agent associated with the development of cirrhosis. Cirrhosis is associated with an increased risk of hepatocellular carcinoma [HCC]. Early detection of HCC in cirrhotic patients can usually be achieved by screening with non invasive techniques such as ultrasound scan and serum alpha-fetoprotein [AFP]. The aim of this study was to determine the plasma levels of immunoreactive matrix metalloproteinase [MMP-9], AFP and basic fibroblast growth factor [FGF] in patients with hepatitis C virus [HCV] infection, liver cirrhosis [LC] and [HCC]. This study included 30 patients with HCV infection, 30 patients with [LC] and 30 patients with HCC. The plasma MMP-9 levels in patients with HCC increase significantly than [LC] group P < 0.05. The plasma AFP levels in patients with HCC were significantly higher than those with hepatitis C group [P < 0.05] and insignificantly higher than those with LC [P > 0.05]. The FGF levels in patients with [LC] were significantly higher than those with [HCV] infection P < 0.01 but FGF level in HCC group increased insignificantly than HCV patients [P > 0.05]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Biomarkers
/
Alpha-Fetoproteins
/
Hepatitis C
/
Carcinoma, Hepatocellular
/
Hepatitis C Antibodies
/
Matrix Metalloproteinase 9
/
Fibroblast Growth Factors
/
Liver Cirrhosis
Type of study:
Screening study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Sci. J. Al-Azhar Med. Fac. [Girls]
Year:
1999
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