Effect of food colouring metanil yellow on the liver and brain of albino rats

ABSTRACT

Forty two adult male albino rats were used in this study and divided into four groups. The first served as a control, the 2[nd], 3[rd] and [4th] were oral treated by metanilyellow for 3, 7 and 15 days. The results showed significant increase of hepatic glutathione peroxidase, lipid peroxidation, glutathione S-transferase, cytochrome P-450 and significant degrease of reduced glutathione content in all treated groups. Also, this study showed significant increase of noradrenaline and significant decrease of dopamine and serotonin in the brain of all treated groups. The present study showed histopathological changes of both liver and brain of albino rats