Predictive value of serum CA 125 and beta subunit of human chorionic gonadotropin in theratened abortion

ABSTRACT

To evaluate the prognostic predictive value of serum beta subunit of human chorionic gonadotropin [beta-hCG] and CA125 in cases with threatened abortion, this study was carried out on twenty women with threatened abortions attending the Obstetrics and Gynecology Department of Tanta University Hospital. Four cases of the twenty patients ended in spontaneous abortion. As regards serum CA125, the mean values were 138.1 +/- 17.79 and 55.5 +/- 4.01 U/ml for spontaneously aborted group [group B] and successful ongoing pregnancy group [group C] respectively, and the mean values of beta-hCG were 22301.9 +/- 2555.1 and 58053.1 +/- 5959.77mIU/ml for group B and group C respectively. There were significant differences between both groups. This study showed that CA125 in more superior to beta-hCG in predicting spontaneous abortion in cases with threatened abortion where its sensitivity and specificity were 100% and 9375% compared to 75% and 37.5 in beta-hCG. Thus, serum CA125 has a high accuracy in predicting the outcome in early threatened abortion