Mimetisme moleculaire entre l'antigene-s et les peptides viraux

ABSTRACT

Experimental autoimmune uveitis [EAU], was induced in Lewis rats after injection of S- Antigen [S-Ag]. In this study we found an amino acid sequence homology between a uveitopathogenic site of S-Ag and two viral proteins. Based on our findings, we conclude that a viral infection may sensitize the mononuclear cells that can cross- react with self proteins by a mechanism termed molecular mimicry