Trichinicidal action of ivermectin

ABSTRACT

The trichinicidal action of the new broad spectrum anthelmintic, Ivermectin, was studied in rats experimentally infected with 100 Trichinella spiralis larvae each. The drug was given subcutaneously at the rate of 0.3 mg/kg b. wt. 2, 7, 14-16 and 21-23 days post infection. The efficiency was found to be 89.4, 91.8, 94.9 and 98.1% on the young intestinal, full developed worms, new encapsulated and encapsulated muscle stages, respectively. The larvae remained in treated rats were surrounded by a defensive tissue reaction and their infectivity was not reduced