Comparative study of apoproteins A and B in diabetic and nondiabetic elderly

ABSTRACT

A clinical thesis was done to study the effect of diabetes mellitus on lipid profile of the elderly particularly apoprotein Al, being the major apoprotein of HDL, and apoprotein B, being the major apoprotein of LDL. The outpatient clinic of Geriatric department of Ain Shams University hospitals was chosen as a scene for this thesis. The lipid profile in diabetic elderly shown by this study is,. increase in cholesterol level, increase in triglyceride level, low HDL level, high LDL, low apo-Al level and increase in apoB as compared to non diabetic elderly. 25% of the diabetics in this study have high cholesterol level as compared to 10% in non diabetics. 15% of the diabetics have high level of'triglycerides as compared to only 5% of the non diabetics. 35% of diabetics have low HDL as compared to 10% in nondiabetics. As for LDL, 15% of the diabetics have high LDL level as comnpared to 5% of non diabetics, 20% of the diabetics tend to have low apo-Al level as compared to only 5% of the non diabetics. As for apoprotein B, 85% of the diabetics have normal level of apo-B, with only 10% of the diabetics having low level of apo-B as compared to 15% of non diabetics. However the mean level of apo-B among diabetics 96.4mg/dl was greater than among non diabetics 78. 7 mg/dl. There were sex variations of the lipid profile of both groups with the females having higher cholesterol, triglycerides, HDL and apo-Al levels and lower LDL and apo-B levels than males