new design form of suppository with sterile gauze-inlay for treatment of hemorrhoids

ABSTRACT

Hemorrhoids are varicosities of the hemorrhoidal venous plexuses, which causes through the heredity, erect posture, chronic constipation, pregnancy, and during childbirth due to persistently increased pressure hemorrhoidal venous plexuses. They are basically classified as externally and internally hemorrhoids. The symptoms of anorectal disease can de relieved using local ointment or suppository. Most of applied suppositories cross the anorectal line of perianal area to the anal canal cavity due to the powerful sphincter muscles. Such local treatment might be have a weak therapeutic response. A new design suppository is developed containing bismuth subgallate, hamamelidis fluid extract, beuzocain, hard fat and sterile gauze, which is immersed in the suppository [3 cm] and 14 cm is remained above the suppository. Such gauze-inlay ensures that the suppository remains in the perianal area to localize and elongate the treatment in the affected area. The clinical study with this new suppository on 60 adult patients with external hemorrhoids and 120 adult patients with internal hemorrhoids [for grad 1,11 and 111] has been demonstrated that these new suppositories have high effective value without any observed side effects, in comparison with the same suppository without gauze- inlay