Correlation between plasma angiotensin II and coronary angiographic findings in patients with essential hypertension

ABSTRACT

The aim of this work,was to evaluate plasma Ang II level in essential hypertensive patients and to verify its relation to the presence and severity of coronary artery disease. Fifty eight patients with essential hypertension and ischaemic chest pain [group A] together with twelve healthy normotensive volunteers [group B] were included in this study.Thorough clinical examination, resting ECG, plain chest X ray, routine laboratory investigations, angiotensin II [Ang II] serum level and echo-Doppler were done for all individuals. Coronary angiography was done fore the group A patients only. The statistical analysis of the results pointed out, a sign higher level of Ang II in group A [38.3 +/- 2 pmol/L] than in group B [24.9 +/- 9 pmol/L] and that its level in group A patients were positively correlated sign to left ventricular mass index and left ventricular wall motion score index but negatively to E/A ratio. Ang II level was significantly higher in hypertensive patients with coronary artery disease [group AII] [59.1 +/- 2 pmol/L] than those with normal coronaries [groupAI] [31.9 +/- 1 pmol/L]. Group All patients with three vessels disease had a sign higher Ang II level than those with two or one vessel coronary artery disease. Ang II level was sign higher in group All patients with LAD coronary artery lesion than those without. ConclustonPatients with essential hypertension had a significantly higher Ang II level than normotensives. Ang II Level was positively correlated significantly to the presence, number and severity of coronary artery lesion in hypertensive patients. Patients with LAD lesion sign had a higher Ang II level than those without