Egyptian Journal of Dermatology and Andrology. 2000; 20 (3): 11-16
in English
| IMEMR
| ID: emr-53632
ABSTRACT
This study aimed to highlight the role of p53 mutations in development and progress of primary cutaneous lymphoma. Cutaneous biopsies of 15 consented patients with primary cutaneous T-cell lymphoma and five normal consented volunteers have been analyzed for p53 immunoreactivity using p53 monoclonal antibodies. The results showed a significant positive correlation between intensity of CD4 monoclonal antibody staining with both nuclear and cytoplasmic p53 overexpression. Accordingly, p53 overexpression may play a role in etiopathogenesis and prognosis of cutaneous T- cell lymphoma. Thus, it may be used as a prognostic marker as well as a monitor of therapeutic response
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Prognosis
/
Skin Neoplasms
/
Biopsy, Needle
/
Immunohistochemistry
/
CD4 Antigens
/
Follow-Up Studies
/
Antibodies, Monoclonal
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Dermatol. Androl.
Year:
2000
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