Effect of C14 ethoxy profenofos insecticides on liver and kidney functions of lactating goats

ABSTRACT

Egyptian healthy baladi goats at the middle of lactating period were classified into two groups, the first group G[1] was kept as non-treated control, while the second group, 6 goats were orally administered the calculated C[14] -Ethoxy profenofos at a dose level 17.9 mg/kg /Body weight/day for 7 successive days. After stoppings of toxicant administration, three goats G2 were sacrificed and the other three animals' G3 were given normal feed for 14 days. Blood samples were taken for determine liver and kidney functions. The distribution of C[14] activity in liver, kidney, fat and muscle tissues showed that the tested organs in G2 contain more C[14] -activity than those in G3. The C[14] -residue levels were found to be high in liver and kidney than in fat and muscle tissues. Significant changes were noticed in GOT, GPT, alkaline Phosphatase, cholesterol, albumin, urea and creatinine during the toxicant administration and returned towards normal values after 14 days recovery