Antioxidant status of children with steroid sensitive nephrotic syndrome

ABSTRACT

The aim of this work was to investigate the changes in lipid peroxidase, catalase, superoxide dismutase together with vitamin A and vitamin C in steroid sensitive nephritic syndrome [SSNS]. The study was carried out on 23 children with SSNS in addition to 23 age and sex matched controls. After a thorough history and clinical examination, all were subjected to laboratory investigations including complete urine analysis, serum creatinine, creatinine clearance, plasma proteins, serum albumin, serum cholesterol, blood catalase [Cat], plasma superoxide dismutase [SOD], plasma lipid peroxide, vitamin C and vitamin A levels. The results showed that serum lipid peroxidase was significantly higher in nephrotic children and maximum increase occurred during relapse. Blood catalase superoxide dismutase, vitamins A and C were significantly lower in nephrotic children compared with the control group and the maximal decrease was during relapse. There was a significant positive correlation between serum catalase and SOD and vitamin C in patients with [SSNS]