Liver large cell dysplasia: a possible premalignant condition: a case report

ABSTRACT

There is still a debate about the role of liver cell dysplasia as a premalignant lesion. A 54 years old Egyptian man with chronic, liver disease was admitted for evaluation of his liver condition. He was diagnosed as liver cirrhosis, portal hypertension and hepatocellular failure. His serum hepatitis B surface antigen was positive and alpha fetoprotein [AFP] level was 200 ng/ml. The histopathological examination of liver biopsy showed liver large cell dysplasia [LCD], which was identified in all histological stenosis on lever power examination. Hepatitis B surface antigen was identified in hepatocytes by orcein stain. It was suggested that cirrhotic patient with liver large cell dysplasia, age above 50 years, hepatitis B surface antigen positive, advanced liver disease and raised AFP level could be major predictors of neoplastic transformation of HCC. Therefore, regular assessment by hepatic ultrasonography and AFP may identify early hepatocellular carcinoma