Iranian Journal of Allergy, Asthma and Immunology. 2000; 1 (2): 69-71
in English
| IMEMR
| ID: emr-53901
ABSTRACT
Interleukin-4 [IL-4] is produced by T-helper cells type 2 [TH2] and induces IgE synthesis. T-helper cells type 1 [TH1] produce interferongamma [IFN-gamma] which suppresses TH2 and reduces IL-4 induced IgE production. In this study, we demonstrated that the levels of specific IgE in the serum of atopic children [n = 20] were elevated while IL-4 production was increased and IFN-gamma secretion was reduced, compared to those of control group. Interleukin -4-induced IGE synthesis by peripheral blood mononuclear cells of atopic children in vitro was blocked in the presence of IFN-gamma. In addition, levels of soluble CD23-which is specifically induced by IL-4, were significantly elevated in our atopic patients. The data indicate that enhanced production of IL-4 and lowered IFN-gamma secretion by T-helper cells correlate with the elevated specific IGE levels in the serum of atopic children
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Asthma
/
Immunoglobulin E
/
Child
/
Rhinitis
/
Cytokines
/
Interleukin-4
/
Interferon-gamma
/
T-Lymphocytes, Helper-Inducer
/
Dermatitis, Atopic
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Iran. J. Allergy Asthma Immunol.
Year:
2000
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