Spectrofluorimetric determination and kinetic study of ceftibuten

ABSTRACT

In this work, a simple and sensitive spectrofluorimetric method was developed to study ceftibuten degradation. It was also applied for the indirect determination of drug in bulk and pharmaceutical capsules. The procedure was based on the reaction of the degraded product with the fluorogenic reagent, fluorescamine. The proposed analytical method was optimized and validated. The detection limit was 0.1035 mug/ml. The activation energy for the degradation was 2.607 Kcal mol1