Effect of non specific immuno-stimulant [isoprinosine] and linseed oil on some immunological aspects in rats

ABSTRACT

In this study, the effect of the immunomodulating agents, isoprinosine and linseed oil was studied in male Sprague- Dawley rats. The LD50 of Proteus mirabilis of both agents was 418 mul of 48 hours growth compared with 296 mul in the control group, accordingly the survival index was calculated and body temperature was recorded. The effect of both compounds on the total body weight, liver, spleen and thymus weights and on the L + S + Thy T ratio in both the normal and bacterially-infected animals was studied as well as their effect on the total leucocytic neutrophilic, lymphocytic and monocytic counts was estimated. The level of serum TNF-alpha and IFN-gamma was measured in both normal and bacterially- stimulated animals. The effect of linseed oil and isoprinosine on cholesterol, triglycerides, HDL-c and LDL-c were evaluated