Beneficial role of L-thyroxine on hepato-renal toxicity induced by amikacin and potassium dichromate

ABSTRACT

Amikacin aminoglycoside antibiotic, potassium dichromate and L- thyroxine were employed to study the induction of hepatonephrotoxicity changes using potassium dichromate; the effect of amikacin sulfate aminoglycoside antibiotic on liver and kidney functions in normal rats and in rats subjected to potassium dichromate induced hepatonephrotoxicity and to minimize the undue effect of both potassium dichromate and amikacin by either concomitant or pre-administration of L- thyroxine. The following test parameters were carried out in serum ALT, AST, isocitrate dehydrogenase, glucose-6- phospatase, total protein, albumin, urea, creatinine and N- acetyl-B- glucosaminidase. The results indicated that the efficient potassium dichromate induced renal impairment required the use of adult rats weighing 250-350 g. The well-marked changes of all the previous test parameters were investigated throughout the experimental period. Among these parameters, serum albumin level seemed to be of a special concern as a risk factor for aminoglycoside nephrotoxicity. The administration of L- thyroxine [10 mug/100 g body wt.] caused an improvement of kidney and liver functions of rats receiving amikacin or potassium dichromate, respectively